SCF complex

Skp, Cullin, F-box containing complex (or SCF complex) is a multi-protein E3 ubiquitin ligase complex catalyzing the ubiquitination of proteins destined for proteasomal degradation. It has important roles in the ubiquitination of proteins involved in the cell cycle and also marks various other cellular proteins for destruction.Morgan, David 'Protein Degradation in Cell-Cycle Control', The Cell Cycle; Principles of Control 2007Hartmut C. Vodermaier (2004). 'APC/C and SCF: Controlling Each Other and the Cell Cycle', Current Biology, 14 (787) Skp, Cullin, F-box containing complex (or SCF complex) is a multi-protein E3 ubiquitin ligase complex catalyzing the ubiquitination of proteins destined for proteasomal degradation. It has important roles in the ubiquitination of proteins involved in the cell cycle and also marks various other cellular proteins for destruction.